煙酸微丸離心造粒工藝研究

【英文篇名】 Preparation of Nicotinic Acid Micropellet by Centrifugal Granulation Technology
【作者】 王甫英; 陳文; 朱忠欣; 肖東; 張銀玲; 彭雪芹;
【英文作者】 Wang Fuying; Chen Wen; Zhu Zhongxin; Xiao Dong; Zhang Yinling; Peng Xueqin （Key Laboratory of Xinjiang Phytomedicine Resources; Shihezi; Xinjiang; China 832002）;
【作者單位】 省部共建新疆特種植物藥資源教育部重點(diǎn)實(shí)驗(yàn)室; 新疆石河子;
【文獻(xiàn)出處】 中國藥業(yè) , China Pharmaceuticals, 編輯部郵箱 2008年 04期 
期刊榮譽(yù)：ASPT來源刊  CJFD收錄刊
【中文關(guān)鍵詞】 煙酸微丸; 離心造粒; 制備;
【英文關(guān)鍵詞】 nicotinic acid micropellet; centrifugal granulation; preparation;
【摘要】 目的制備煙酸微丸并考察其溶出度。方法采用離心造粒法,以微丸產(chǎn)率、休止角、堆密度、脆碎度等為指標(biāo)考察影響微丸成型過程的處方因素和工藝因素,并采用紫外分光光度法測定溶出度。結(jié)果成丸的優(yōu)化處方和工藝參數(shù)是,煙酸與微晶纖維素(MCC)的比例為10∶1(w/w),黏合劑為3%羥丙基甲基纖維素(HPMC,5mPa·s)的20%乙醇溶液,主機(jī)轉(zhuǎn)速為251r/min,風(fēng)機(jī)轉(zhuǎn)速為476r/min,噴氣壓力為0.01～0.04MPa,噴漿泵頻率為5.00～10.00Hz,供粉機(jī)轉(zhuǎn)速為15.00～20.00r/min。結(jié)論在優(yōu)化條件下采用離心造粒法可制備出表面光滑、圓整度好的煙酸微丸,18～24目微丸收率可達(dá)90.8%,溶出度符合2005年版《中國藥典(二部)》要求。
【英文摘要】 Objective To prepare nicotinic acid micropellet and to research the release rate.Methods Nicotinic acid micropellet were prepared by using centrifugal granulator.The composition and process factors were optimized by adopting several indices such as yield, repose angle,bulk density and friability.Results The optimal process parameters were as follows:nicotinic acid and MCC was 10 ∶1(w/w),binder solvent was 3% HPMC 20% ethanol solution,rotor rotation speed was 251 r/min,slit air flow rate was 476 r/min,spray ...
【基金】 新疆兵團(tuán)醫(yī)藥衛(wèi)生專項(xiàng)課題基金,項(xiàng)目編號(hào):05GG39
【DOI】 CNKI:SUN:YYGZ.0.2008-04-033
【正文快照】 作為一種制粒方式,微丸制備技術(shù)與常規(guī)制粒技術(shù)有所區(qū)別,它是將顆粒制成球形或類球形且粒度分布更窄,一般直徑在0.5～1.5mm,不超過2.5mm[1]。微丸劑與其他口服制劑比較,具有外形美觀、流動(dòng)性好、釋藥穩(wěn)定、生物利用度高、局部刺激性小等優(yōu)點(diǎn),采用不同的材料對微丸包衣還可達(dá)到